Background: Human immunodefi ciency virus (HIV) is a retrovirus, identifi ed in 1982, oral manifestations include postsurgical complications and special care to a safe surgical intervention should be followed, making it the most favorable prognosis. Methods: This review is to evaluate the cases published in world scientifi c literature involving HIV+ patients undergoing therapy with dental implants and their reactions, compared to patients without this disease. Moreover, reports the planning, implementation and follow-up of 36 months of a case with immediate load fi xed full arch prosthesis in complete edentulous lower jaw with three implants on HIV+ patient. Results: A 56 years old, toothless in both jaws. All serologic and clinic examinations were favorable, as well as the X-ray examinations, without pathological changes or bone problems. Treatment plans was a complete denture maxillary and immediate load with implants mandibulary. Three implants 3.75 diameter ×15 mm length, one in a median region, and two tilted to distal, bilaterally to reduce the cant-lever were performed, abutments installed and provided the fi nal prosthesis after molding to delivery on the next day. Conclusion: The patient reports complete comfort with prosthesis, the knowledge of hygiene techniques available to the longevity of the case, and the improvement in their overall health with implants, because feeds more and better, with a suitable grinding food providing a better health for treatment against HIV. The dental implants show great option for the rehabilitation of these patients as demonstrated in this review, and reporting and monitoring of 36 months immediate loading.